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Synaptic and extrasynaptic NMDAR activation exert opposing neural protective and neurotoxic effects, respectively, and these processes involve a variety of corresponding neuroprotective and apoptotic pathways ( Metabotropic Glutamate Receptors Glutamate can also activate a type of G-protein-coupled receptors known as metabotropic glutamate receptors (mGluRs)

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Research shows that hexarelin does not significantly increase appetite compared to peptides like GHRP-6 [5]